The use of therapeutic apheresis (TA) is growing every year and increasing evidence shows that it’s being used as a primary therapy or adjunct to other therapies for various conditions that impact neurologic, hematologic, oncologic, rheumatologic, and renal systems. Apheresis is a procedure with significant physiologic outcomes, so the care of TA patients requires knowledge and skill of leading practices and innovative devices. This educational activity will discuss the rationale for TA procedures and the nursing considerations in the delivery of apheresis care. Access methods will be reviewed along with the risks and adverse events associated with vascular access procedures.