Laparoscopic Cholecystectomy (LC) is the go-to treatment for gallstones and other gallbladder diseases. While LC has become a very common procedure, often performed in outpatient settings, it still presents risks for the patient. Every member of the perioperative team, including—RNs, Surgical Technologists and Sterile Processing professionals—plays a critical role in optimizing the safety and efficacy of LC. This learning activity will discuss the incidence and prevalence of symptomatic gallstones, the key surgical techniques established to ensure safe gallbladder removal, and the critical safety aspects and activities for laparoscopic instrument reprocessing and surgical supplies—such as cystic duct clips—that help every LC patient avoid complications and experience an optimal postoperative outcome.