Clostridium difficileinfection is recognized as one of the most serious healthcare-associated infections occurring around the world today. Infections may be mild and resolve fairly rapidly after antibiotic cessation, or may be severe, lingering and life-threatening. Emergence of new strains with increased virulence, sporulation frequency and antibiotic resistance along with increased patient vulnerabilities, altered healthcare practices and new reservoirs are all contributing to the aggressive success of this not-so-glamorous superbug. The purpose of this educational program is to discuss the impact of Clostridium difficile,describe its new strains, recommend best practices and describe new technologies designed to prevent transmission.