This session was presented at the November 2012 Managing the Spectrum of Infection Prevention in Acute and Ambulatory Settings symposium held in Atlanta. The focus of this session, Infection Prevention: An International Perspective, was on the speaker’s experiences with infection prevention challenges that have evolved into international issues beyond being a domestic problem. This program traces the fallacy of the end of infectious diseases to the new consensus of the relationship between U.S. health and global health. The major factors contributing to the emergence of infectious diseases worldwide will include human demographics, behavior, and society; technology and industry; environmental factors; international travel; microbial adaptation and change; and the breakdown of public health measures. Antimicrobial resistance in terms of mortality risk and the cost of MDRO infections will be explored. The international issues related to disease risks associated with medical tourism and mass gathering infection risks will be presented. The global burden of healthcare associated infections (HAIs) and shared challenges of antibiotic resistance and infection intervention strategies will be described. This videotaped presentation will be enhanced with synchronized audio recordings and PowerPoint slides. The participant will complete test questions and a course evaluation form to measure the value of this learning experience.