This session was presented at the November 2012 Managing the Spectrum of Infection Prevention in Acute and Ambulatory Settings symposium held in Atlanta. The focus of this session, Impact of Healthcare Reform on Infection Prevention, was on how healthcare reform will impact infection prevention. This program reviews surgical site infection (SSI) statistics and the legislation from 2005 to 2015 that plays a role in the prevention of hospital acquired infections (HAIs). The discussion offers highlights of the 2005 Deficit Reduction Act; the American Recovery and Reinvestment Act (ARRA 2008); Phases I and II of the Health and Human Services (HHS) Action Plan to Prevent HAIs (2009); Accountable Care Act (Obamacare 2010); Partnership for Patients (2011); other hospital initiatives such as Value Based Purchasing (2013) and reduced reimbursement for Hospital Acquired Infections (2015). Ambulatory surgery issues will be addressed along with state health department compliance requirements. Phase I HHS progress toward nine national targets will be presented. The Agency for Healthcare Research and Quality (AHEQ) funded report with a promising computer algorithm for predicting the potential for patients at high risk for hospital acquired infection and the advantages of surveillance automation will be described. This videotaped presentation will be enhanced with synchronized audio recordings and PowerPoint slides. The participant will complete test questions and a course evaluation form to measure the value of this learning experience.