This session was presented at the November 2012 Managing the Spectrum of Infection Prevention in Acute and Ambulatory Settings symposium held in Atlanta. The focus of this session, Disease Transmission in Our Shrinking World, was on disease transmission related to global travel. This presentation offers highlights of specific diseases transmitted due to our modern age of travel; reviews food borne, vector borne, and travel related infectious disease scenarios; addresses common disease situations of concern to healthcare facilities and staff; discusses some basic epidemiological principles for application to disease clusters and outbreaks; and provides numerous resources for reporting and gathering information on diseases and CDC projects that support public health. This videotaped presentation will be enhanced with synchronized audio recordings and PowerPoint slides. The participant will complete test questions and a course evaluation form to measure the value of this learning experience.