Collaboration is an essential element of a high-functioning healthcare team. The COVID-19 pandemic has emphasized the importance of collaboration between infection prevention and environmental services in developing strategies to combat the spread of infectious diseases within a healthcare facility. This session will discuss trends in cleaning and disinfection, outline newer technologies than can facilitate cleaning and disinfection, and best practices for training staff in breaking the chain of infection. A panel discussion with three infection preventionists from across the United States will share challenges and successes in environmental cleaning and disinfection during the COVID-19 pandemic.