Chronic rhinosinusitis (CRS) is a widespread, debilitating disease that can significantly affect a person’s quality of life. The care pathway for patients with CRS involves a complex combination of medical and surgical therapy. While functional endoscopic sinus surgery (FESS) is a recognized treatment for CRS and various sinus disorders, the majority of these patients have symptom recurrence typically within one year after surgery, resulting in poor outcomes. Therefore, numerous perioperative techniques aimed at maintaining surgical outcomes are generally employed to facilitate postoperative outcomes. The purpose of this continuing nursing education activity is to provide a review of the role of drug delivery following FESS in optimizing patient outcomes. An overview of the anatomy and physiology of the paranasal sinuses, followed by the clinical implications of CRS, will be presented. The care pathway for CRS patients will be outlined, including the indications for FESS and the clinical considerations related to continued medical therapy. The various drug classes and routes of administration to the sinuses postoperatively will be reviewed and the clinical support data documented in the literature.